- Familial adenomatous polyposis (FAP) is a rare hereditary disease caused by a defect in the adenomatous polyposis coli (APC) gene. Most people inherit the gene from a parent. However, the genetic mutation occurs spontaneously in 25 to 30% of people.
- FAP causes extra tissue (polyps) to form in the large intestine (large intestine) and rectum. Polyps can also appear in the upper gastrointestinal tract, especially the upper part of your small intestine (duodenum). If left untreated, colon and rectal polyps are likely to become cancerous by the age of 40.
- Most people with familial adenomatous polyposis eventually need to have surgery to remove the colon and prevent cancer. Duodenal polyps can also develop cancer, but can usually be managed with careful monitoring and regular removal of the polyps. Familial adenomatous polyposis treatment in Hyderabad
Some people have a milder form of the disease called attenuated familial adenomatous polyposis (AFAP). People with AFAP usually have fewer colon polyps (an average of 30) and develop cancer later in life.
The main signs of FAP are the hundreds, if not thousands, of polyps that grow in your colon and rectum, usually from your teenage years. Polyps are almost 100% sure to turn into colon cancer or rectal cancer by the time you are in your forties. Familial adenomatous polyposis treatment in Hyderabad
Familial adenomatous polyposis is caused by a defect in a gene that is usually inherited from a parent. However, some people develop the abnormal gene that causes the disease.
Your risk of familial adenomatous polyposis is higher if you have parents, children, or siblings with the disease.
In addition to colon cancer, familial adenomatous polyposis can cause other complications:
Duodenal polyps. These polyps grow in the upper part of your small intestine and can become cancerous. However, with careful monitoring, duodenal polyps can often be detected and removed before cancer develops.
Periampullary polyps. These polyps occur where the biliary and pancreatic ducts enter the duodenum (bladder). Periampullary polyps can become cancerous, but can often be detected and removed before cancer develops.
Stomach Fundic Polyps. These polyps grow in the lining of the stomach.
Desmoids. These non-cancerous masses can appear anywhere in the body, but they often develop in the stomach area (abdomen). Desmoids can cause serious problems when they transform into nerves or blood vessels, or when they put pressure on other organs in your body.
Other cancers. In rare cases, FAP can cause cancer of the thyroid gland, central nervous system, adrenal glands, liver, or other organs to develop.
Prevention of FAP is not possible because it is an inherited hereditary disease. However, if you or your child are at risk of AFP because of a family member with the disease, you will need genetic testing and advice.
If you have FAP, you will need to be checked regularly, followed by surgery if necessary. Surgery can help prevent colon cancer or other complications from developing. Familial adenomatous polyposis treatment in Hyderabad