Krabbe disease Treatment in Hyderabad


Krabbe disease (KRAH-buh) is a hereditary disease that destroys the protective layer (myelin) of the nerve cells in the brain and in the entire nervous system.

In most cases, the signs and symptoms of Crab Disease in babies develop before 6 months of age, and the disease usually results in death by 2 years of age. If it develops in older children and adults, the course of the disease can vary widely.

There is no cure for crab disease and treatment focuses on supportive care. However, stem cell transplants have shown some success in infants treated before symptoms appear and in some older children and adults.

Crab disease affects about 1 in 100,000 people in the United States. It is also known as globoidal cell leukodystrophy.


In most cases, the signs and symptoms of Krabbe disease appear within the first 2 to 5 months of life. You start gradually and gradually.

Common signs and symptoms at the onset of the disease are:

The reasons

Krabbe disease is caused when a person inherits two copies of an altered (mutated) gene – one copy from each parent.

A gene provides a kind of model for the production of proteins. If there is a flaw in this plan, the protein product may not work properly. In the case of Krabbe disease, two mutated copies of a particular gene result in little or no production of an enzyme called galactocerebrosidase (GALC). Krabbe disease Treatment in Khammam

Enzymes like GALC are responsible for breaking down certain substances in the recycling center of a cell (lysosome). In Krabbe disease, the lack of GALC enzymes leads to the formation of certain types of fats called galactolipids.

Risk factors

If every parent has a mutated copy of the gene, the risk to a child would be as follows:

Leave a Reply

Your email address will not be published. Required fields are marked *