In a kidney
Kidney cross section Open popup dialog
Nephrotic syndrome is a kidney disease in which your body gets too much protein in your urine.
Nephrotic syndrome is usually caused by damage to the clumps of small blood vessels in your kidneys that filter waste and excess water from your blood. The disease causes swelling, especially on the feet and ankles, and increases the risk of other health problems. Nephrotic syndrome Treatment in Hyderabad
Signs and symptoms of nephrotic syndrome include:
- Severe swelling (edema), especially around the eyes, ankles and feet
- Foamy urine, a result of excess protein in your urine
- Weight gain from water retention
- Loss of appetite
Nephrotic syndrome is usually caused by damage to the clumps of small blood vessels (glomeruli) in your kidneys.
Glomeruli filter your blood as it circulates through your kidneys, separating the things your body needs from the things it doesn’t. Healthy glomeruli prevent blood proteins (mainly albumin), which are needed to maintain the right amount of fluids in your body, from getting into your urine. When the glomeruli are damaged, too much blood protein can leak out of your body, leading to nephrotic syndrome.
Factors that can increase your risk of developing nephrotic syndrome include:
- Conditions that can damage your kidneys. Certain diseases and conditions increase the risk of developing nephrotic syndrome, such as diabetes, lupus, amyloidosis, reflux nephropathy, and other kidney diseases.
- Certain drugs. Drugs that can cause nephrotic syndrome include nonsteroidal anti-inflammatory drugs and drugs used to fight infections.
- Certain infections. Infections that increase the risk of developing nephrotic syndrome include HIV, hepatitis B, hepatitis C, and malaria.
The possible complications of nephrotic syndrome are:
- Blood clot. The inability of the glomeruli to properly filter the blood can lead to a loss of blood proteins that help prevent clotting. This increases the risk of developing a blood clot in your veins.
- High blood cholesterol and high blood triglycerides. When the level of protein albumin in your blood decreases, your liver produces more albumin. At the same time, your liver releases more cholesterol and triglycerides.
- Bad diet. Losing too much protein in the blood can lead to malnutrition. This can lead to weight loss, which can be masked by edema. You may also have too few red blood cells (anemia), low blood protein levels, and low vitamin D levels.
- Arterial hypertension. Damage to your glomeruli and the resulting build-up of excess body fluid can raise your blood pressure. Nephrotic syndrome Treatment in Hyderabad