Primary ovarian failure – also known as premature ovarian failure – occurs when the ovaries stop functioning normally before the age of 40. When this happens, your ovaries are not producing normal amounts of estrogen and are not releasing eggs on a regular basis. This condition often leads to infertility.
Primary ovarian failure is sometimes confused with premature menopause, but these conditions are not the same. Women with primary ovarian failure can have irregular or occasional periods for years and even become pregnant. However, women with premature menopause stop menstruating and cannot get pregnant. Primary ovarian insufficiency Treatment in Nizamabad
Restoring estrogen levels in women with primary ovarian failure helps avoid certain complications that result from low estrogen levels such as osteoporosis.
The signs and symptoms of primary ovarian failure are similar to those of menopause or lack of estrogen. They include:
- Irregular or skipped periods that can last for years or develop after pregnancy or after stopping birth control pills
- Difficulty getting pregnant
- Hot flashes
- Night sweats
- Vaginal dryness
- Dry eyes
- Irritability or difficulty concentrating
- Decreased sexual desire
Primary ovarian failure can be caused by:
Chromosome defects. Some genetic disorders are associated with primary ovarian failure. These include Mosaic Turner Syndrome, in which a woman has only one normal X chromosome and an altered second X chromosome, and fragile X syndrome, in which the X chromosomes are fragile and break.
The toxins. Chemotherapy and radiation therapy are common causes of toxin-induced ovarian failure. These therapies can damage the genetic material of cells. Other toxins like cigarette smoke, chemicals, pesticides, and viruses can speed up ovarian failure.
An immune system response to ovarian tissue (autoimmune disease). In this rare form, your immune system makes antibodies against your ovarian tissue, causing damage to the follicles that contain the egg and damaging the egg. It is not clear what triggers the immune response, but exposure to a virus is possible.
Factors unknown. The cause of primary ovarian failure is often unknown (idiopathic). Your doctor may recommend additional tests to find the cause, but in many cases the cause is unclear. Primary ovarian insufficiency Treatment in Nizamabad
Factors that increase your risk of developing primary ovarian failure include:
Age. The risk increases between 35 and 40 years. Although rare before age 30, primary ovarian failure is possible in younger women and even in adolescent girls.
Family history. A family history of primary ovarian failure increases the risk of developing the disorder.
Ovarian surgery. Surgery on the ovaries increases the risk of primary ovarian failure.