Pseudocholinesterase Deficiency (Soo-Doe-Koh-Lin-ES-Tur-Ays) is a rare condition that makes you sensitive to certain muscle relaxants – succinylcholine or mivacurium – used during anesthesia. Medicines are designed to briefly relax your muscles during a medical procedure. With a pseudocholinesterase deficiency, the muscles in the body stay relaxed longer. Paralysis of the respiratory muscles prevents you from breathing. Pseudocholinesterase deficiency Treatment in Nizamabad
Pseudocholinesterase deficiency can be caused by a genetic defect (mutation) inherited or acquired due to illness, injury, or certain medications.
There is no cure for pseudocholinesterase deficiency. If you are diagnosed with the disease, your doctor may use other types of muscle relaxants that do not cause prolonged muscle relaxation.
Most people with pseudocholinesterase deficiency will not have any signs or symptoms of the disease until they are exposed to the muscle relaxants succinylcholine or mivacurium. These drugs are used as part of anesthesia. Signs and symptoms include muscle relaxation or paralysis that lasts for several hours and is unable to breathe on its own. The duration of muscle relaxation can vary widely in people with this deficiency.
When you are pseudocholinesterase deficient, your body lacks or lacks a reduced amount of the enzyme that is needed to break down (metabolize) drugs called choline esters. These drugs, succinylcholine and mivacurium, are used in anesthesia to relax muscles during medical procedures. Pseudocholinesterase deficiency Treatment in Nizamabad
A lack of pseudocholinesterase causes the muscles to remain relaxed for too long, making it difficult for you to move or breathe on your own for a few hours after receiving the medicine. The time it takes your body to metabolize the drug depends on how much pseudocholinesterase enzyme is produced and how well it is working.
Your risk of developing pseudocholinesterase deficiency is higher if you or a first-degree relative, such as a parent, child, or sibling:
- An abnormal gene associated with the disease
- A history of an event during anesthesia that suspected pseudocholinesterase deficiency
If you have a family history of pseudocholinesterase deficiency, or if a family member has had problems with anesthesia, talk to your doctor before undergoing any medical procedure that requires general anesthesia. If you have a family history of pseudocholinesterase deficiency, you can avoid problems during anesthesia by doing pre-procedure tests. Pseudocholinesterase deficiency Treatment in Nizamabad
By assessing your risk for pseudocholinesterase deficiency, your anesthetist can avoid certain medications if necessary.